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What we Know about cannabinoids

Where To Start

CBD Living Immune Boost

There’s a lot of stuff in CBD, what are cannabinoids in general? Hemp and MMJ products are similar but not the same. A brief post about the differences between the cannabinoids, and the studies still being done to determine their benefits will suit my audience greatly.

What We Know The Most About So Far

CBD 

I have lots of information about what CBD is but, let’s go over the general idea of what CBD does. Understanding the ECS or Endo-Cannabinoid System is a great place to start. One way to think about this system is Tetris. Blocks falling into place and either making perfect patterns or falling into places that leave open spaces. The main thing about CBD is it doesn’t fit into a perfect square. THC when entering the ECS makes a perfect square and you get “TETRIS” or the high associated with it.

CBD doesn’t get you the “TETRIS” so to say. It makes empty places in the ECS like when you mess up a piece playing. It’s also important to note that just like Tetris your body creates these blocks on its own.

They’re what’s responsible for what some call a jogging high. That feeling is indigenous cannabinoids flooding the bloodstream. CBD doesn’t make full connections. It doesn’t give you the “TETRIS” but it blocks other cannabinoids from getting in and getting out.

It also makes your body produce more of these natural accruing cannabinoids in the brain. It’s actually quite amazing.

It’s important to note that we know so much about CBD because of the research allowed to be done. Once they’ve identified all the things CBD can do they’ll research some of the less abundant ones. We do know a little bit about a lot of them so let’s go to CBG.

CBG (Cannabigerol)

Unlike CBD, CBG isn’t very prevalent in hemp flowers. They assume it accounts for about 1% of the cannabinoids in most hemp plants. They call these Minor Cannabinoids. CBG is interesting because it’s the precursor to CBD or THC. Depending on many factors CBG is either converted into one or the other.

How does CBG compare to CBD?

CBD and CBG are both non-intoxicating cannabinoids… They also both interact with the same receptors in the body. According to a 2018 study from Front Pharmacol, they appear to have anti-inflammatory effects.

However, CBG does seem to have some different functions and health benefits than CBD.

The main difference between CBD and CBG comes down to the level of research available. There’s been a decent amount of research on CBD, but not so much on CBG. 

That said, with CBG becoming more popular, there will likely be more studies on it soon.

While the research on CBG is limited, studies do exist suggest that it offers several benefits. 

CBG may be able to improve the following health conditions:

  • Inflammatory bowel disease. CBG seemed to reduce the inflammation associated with inflammatory bowel disease, according to a 2013 study conducted by Biochem Pharmacol.
  • Glaucoma. Medical cannabis seems to help treat glaucoma, and CBG might be partly responsible for its efficacy. An abstract study published in 2008 suggests that CBG might be effective in this treatment. Due to its ability to reduce intraocular pressure. 
  • Bladder dysfunctions. Studies showed cannabinoids seem to affect the contractions of the bladder. An abstract 2015 study looked at how five different cannabinoids affect the bladder. It showed that CBG has the most promise at treating bladder dysfunctions.
  • Huntington’s disease. CBG might even have neuroprotective properties, according to a 2015 study with a neurodegenerative condition called Huntington’s disease. The study showed that CBG might show promise in treating other neurodegenerative conditions.
  • Bacterial infections. A 2008 study suggested that CBG might kill bacteria. In particular a drug-resistant staph infection particularly methicillin-resistant Staphylococcus aureus (MRSA). These infections can be hard to treat and fairly dangerous. 
  • Cancer A 2014 study out of Madrid Spain looked at colon cancer in rats. It showed that CBG could reduce the growth rate of cancer cells and other tumors.
  • Appetite loss. A 2016 study on rats done by Psychopharmacology in (Berlin) suggested that CBG could stimulate the appetite. Appetite-stimulating chemicals could be used to help those with conditions such as HIV, cancer, even eating disorders.

While these studies are promising, it’s important to remember that they don’t confirm the benefits of CBG. Much more research is needed to fully understand how CBG works in the body.

CBN (Cannabinol)

THC and CBD, aren’t the only cannabinoids produced by the plant. You’ll also find minor cannabinoids, like CBN (cannabinol), among others. CBN is used as a sleep aid in our Sleep Well line from Lyft CBD. They have a tincture in two strengths and flavors. My personal favorite is The CBN Sleep Well Disposable Pen. I’ve tried everything for my insomnia. Lately, I’ve found that little bit of hemp flower before I’m ready to sleep. Two to three puffs off of the Sleep Well Pen and I’m asleep in 10-15 min every night.

These medicinal compounds, unique to cannabis alone, can be very different from each in their effects and medicinal benefits. So, if you want to know how your cannabis will affect you. Learning about the different cannabinoids is the first step.

So, let’s get to a first name basis with CBN.

What Is CBN (Cannabinol)

If you use cannabis, take CBD, or have been reading any of my blogs. You’ve probably heard all about its two most popular cannabinoids. THC and CBD. But these aren’t the only cannabinoids produced by the plant. You’ll also find minor cannabinoids, like CBN (cannabinol), among others.

These medicinal compounds are unique to cannabis alone. can be very different from each other in terms of their effects and medicinal benefits. So, if you want to know how your cannabis will affect you, learning about the different cannabinoids is the first step.

So, let’s get to know CBN a little better.

What Are the Potential Benefits of CBN (Cannabinol)?

CBN is another non-intoxicating cannabinoid that is best known for being created as THC ages. It’s usually present in high amounts in older cannabis. While this might be a turn-off for some, others, like me Seek out older cannabis just to enjoy the effects of CBN. Mostly the powerful sedative effects it has alone.

Here are a few of the potential benefits of CBN currently being explored in research. Keep in mind during this entire article, research on CBN and most cannabinoids is limited with very few studies demonstrating its effects in the human body. Related The most impactful cannabis studies of all time

Antibacterial

Studies on CBN have found that it may be a potent antibacterial agent. In lab settings, CBN was tested on strains of MRSA bacteria that are resistant to traditional antibiotics. Researchers found it to be a potent antibacterial agent against these resistant strains. Perhaps in the future, we will see CBN being used to fight off bacterial infections that our usual antibiotics can’t heal.

Neuroprotectant

CBN may also be a powerful neuroprotectant. In one rodent study, researchers used CBN as a treatment for ALS and found that it was able to delay the onset of the condition. While human studies need to be done, this suggests that CBN may provide a powerful tool in the fight against ALS and other neurodegenerative conditions.

Appetite Stimulation

In rodent studies, CBN increased the amount of food that rat subjects ate, suggesting that it could be an effective appetite stimulant. Since some avoid THC (another well-known appetite stimulant) due to its intoxicating effects, CBN could provide a better solution for those seeking the benefits without the high—but more research is needed.

CBC (Cannabichromene) What Is CBC? What Are the Benefits of This Cannabinoid?

CBC Works With Other Cannabinoids and is non psychoactive

The reason it is non-intoxicating is because it binds poorly to CB1 cannabinoid receptors in the brain.

CBC does bind with other receptors in the body, such as the vanilloid receptor 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1), both of which are linked to pain perception.

When CBC activates these receptors, increased levels of the body’s natural cannabinoids like anandamide ( a naturally occurring cannabinoid in the body) are released.

While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term is known as the entourage effect. As I’ve said here many times, this is something I’m not quite on board with.

I do think that other cannabinoids will play a factor but not as much as terpenes as we mentioned in the blog linked here. This effect of CBD, CBN, and CBG working together is well-known, but whether other cannabinoids have entourage effects is not well understood. I think they need to study more into the effects of terpenes and cannabinoid interactions before we fully understand the Entourage Effect.

CBC’s Medicinal Potential

The purported benefits of CBC have far-reaching implications. Below are a few medical conditions that may be alleviated by cannabichromene.

Cancer

Cannabichromene may be a powerful cancer fighter, and the reason might be its interaction with the body’s natural endocannabinoid, anandamide. CBC also appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream.

A recent study in which tumor growth was initiated in mice (two-stage mouse skin carcinogenesis model) showed cannabinoids might be effective in inhibiting both inflammation and tumor growth. Since anandamide has been shown to fight breast cancer in vitro and in vivo, this shows promise that CBC and other cannabinoids might one day be a chemopreventive agent.

CBC as a potential cancer fighter was first published in a 2006 study that looked at cannabinoids other than THC and their possible effects on cancer. While THC is known for its anti-tumor properties for several different forms of cancer, its powerful psychotropic qualities can make it difficult for chemotherapy use.

So far, research has found CBC to be the second-most-potent cannabinoid at inhibiting the growth of new cancer cells (CBG was the most potent).

Pain and Inflammation

Cannabichromene has been shown to block pain and inflammation associated with collagen-induced osteoarthritis. Cannabinoids like CBC act on inflammation differently than non-steroidal anti-inflammatory drugs (NSAIDs) do, and don’t have the side effects of these medications.

In another example of the entourage effect, CBC in combination with THC had a significant anti-inflammatory response in a recent animal study; together, the two cannabinoids produced a much greater effect on inflammation than by themselves.

Brain Cells

In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis.

The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteracts many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.

Acne

A research team that had previously shown CBD’s effect on acne studied other cannabinoids, including CBC, for the same effects. Indeed, CBC was shown to be a powerful inhibitor of acne.

As a skin disease, acne is characterized by excess sebum production and sebaceous gland inflammation. It turns out that CBC exhibited powerful anti-inflammatory properties and also suppressed excessive lipid production in the sebaceous glands. CBC also reduced levels of arachidonic acid (AA), which is needed to create lipogenesis.

More research is needed, but CBC might just one day become a very powerful anti-acne treatment.

Depression

In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties. Maybe leading to a low dose THC high dose CBD and CBC medication one day.

Needless To Say There’s Still A Lot of Work To Be Done

Here I’ve covered only four cannabinoids that are being studied but the list gets big. I’ve done a blog on CBD-A here but there’s THC-A that has no psychoactive effects whatsoever unless heated. There are the acidic versions of all of the ones covered here like CBG-A. There are CBL and CBDV but I don’t want you getting too bored reading this. I’ve linked good articles to the ones I haven’t covered yet but would like to more of these when more information becomes available. Until then, I hope this quells any doubts you had about tried a CBD product.

So To Conclude

It’s not Marijuana, it’s so much more and more than that. I couldn’t thank the people involved in providing these products enough as they have helped with my depression, anxiety, pain, nausea, and a number of other things I experience less daily. Without CBD I wouldn’t be running this store or writing this blog.

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